Deuterium magnetic resonance spectroscopy for assessing glucose metabolism in healthy and in neurooncology diseased brain. Review

Aim: to present a new method for assessing glucose catabolism in brain tissues of healthy volunteers and neurooncology patients. This is MR spectroscopy with resonance frequency deuterium (hydrogen isotope) called metabolic imaging - DMI. Material methods. We searched scientific papers PubMed Google Scholar indexing systems 2017–2022 publicatioin years. Keywords used: spectroscopy, DMI, DMV, PET, non-proton tumor metabolism, Warburg effect tumor, glucose/glucolytic flux/metabolism. Results. 474 articles were analyzed, 21 which used this review. The references list additionaly includes 9 1924–2014 pyublication review covers the history proton multinuclear (phosphorus, carbon, deuterium) development PET diagnostics. described DMI applicability visual quantitative assessment tissue metabolism disorders tumors discussed its future use clinical practice. Conclusion. Compared fluorodeoxyglucose (FDG) provides additional information on during anaerobic glycolysis tumor. can be implemented performed MRI scanners.